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[Pharmacokinetic study of cefsulodin in children]
Insights
Cefsulodin (CFS) pharmacokinetics in children show higher serum clearance and distribution volume compared to adults. Urinary excretion percentages were similar to adult values, indicating effective drug elimination.
Area of Science:
- Pharmacology
- Pediatric Pharmacokinetics
- Antibiotic Research
Context:
- Cefsulodin (CFS) is a cephem antibiotic used in pediatric care.
- Understanding pediatric drug pharmacokinetics is crucial for safe and effective treatment.
- Limited data exists on Cefsulodin pharmacokinetics specifically in children.
Purpose:
- To investigate the serum and urinary concentrations of Cefsulodin in pediatric patients.
- To determine the pharmacokinetic parameters of Cefsulodin following intravenous administration in children.
- To compare pediatric pharmacokinetic data with existing adult data.
Summary:
- Cefsulodin was administered to 26 children (11 months to 11 years) via IV injection or infusion at 15 and 50 mg/kg.
- Serum concentrations peaked post-infusion, with biological half-lives around 1.2-1.3 hours.
- Pediatric serum clearance was approximately double that of adults, and distribution volume was 1.5 times larger.
Impact:
- Provides essential pharmacokinetic data for Cefsulodin dosing in pediatric populations.
- Highlights differences in drug metabolism and distribution between children and adults.
- Informs clinical practice for optimizing Cefsulodin therapy in pediatric patients.
Abstract:
Cefsulodin (CFS), a cephem antibiotic, was administered to 26 children aged from 11 months to 11 years by intravenous injection or intravenous 1-hour drip infusion in doses of 15 and 50 mg/kg body weight to investigate serum and urinary concentrations. The following results were obtained. Serum concentration The serum concentrations of CFS at 5 minutes after intravenous injection of 15 and 50 mg/kg were 57.1 and 224.2 micrograms/ml, respectively. The biological half-lives (T 1/2 beta) were 1.28 and 1.12 hours. The serum concentration of CFS after intravenous 1-hour drip infusion reached a peak at the end of infusion, i.e. 29.9 micrograms/ml for 15 mg/kg and 121.9 micrograms/ml for 50 mg/kg, and T 1/2 beta were 1.22 hours for 15 mg/kg and 1.27 hours for 50 mg/kg. The AUC was proportional to the doses for both intravenous injection and intravenous drip infusion. The serum clearance was about twice the value in adults and the distribution volume was about 1.5 times as large. Urinary excretion The urinary excretion up to 6 hours after administration was: 69.0% for 15 mg/kg and 61.9% for 50 mg/kg in cases of intravenous injection, and 62.4% for 15 mg/kg and 71.1% for 50 mg/kg in cases of intravenous 1-hour drip infusion. The percent urinary excretion was similar to that in adults.