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Useful Bowel Preparation with Ultralow-Volume (500 mL) Polyethylene Glycol for Colonoscopy: A Retrospective Study.

Yusuke Mizuno¹, Takaya Shimura¹, Takayuki Nukui¹

¹Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Digestive Diseases (Basel, Switzerland)

|February 3, 2025

Summary

This study shows an ultralow-volume polyethylene glycol (PEG) bowel preparation is effective for colonoscopy. The regimen achieved a 91.8% adequate preparation rate with minimal side effects.

Keywords:

500 mL Bowel preparation Colonoscopy Polyethylene glycol Ultralow-volume

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Published on: September 21, 2015

Area of Science:

Gastroenterology
Endoscopy
Pharmacology

Background:

High-quality colonoscopy relies on effective bowel preparation.
An ultralow-volume (500 mL) polyethylene glycol (PEG)-based regimen with additional laxatives has been used for 30 years.
This study evaluates the clinical effectiveness of this established bowel preparation method.

Purpose of the Study:

To assess the effectiveness and safety of a specific ultralow-volume bowel preparation regimen for colonoscopy.
To determine the rate of adequate bowel preparation using the Boston Bowel Preparation Scale (BBPS).

Main Methods:

A retrospective analysis of 773 outpatients undergoing colonoscopy between January and December 2022.
Patients received sennoside, sodium picosulfate, and 500 mL PEG with lactulose.
Bowel cleanliness was assessed using the BBPS, with adequate preparation defined as a total score ≥6.

Main Results:

An adequate bowel preparation rate of 91.8% was achieved in 773 patients.
50.5% of patients received a perfect BBPS score of 9.
The ultralow-volume PEG regimen demonstrated a low incidence of side effects (e.g., vomiting in 3 patients).
Independent risk factors for inadequate preparation included age ≥70, diabetes, and diverticula.

Conclusions:

The 500 mL PEG-based ultralow-volume bowel preparation is a safe and effective method.
This regimen is suitable for routine clinical use in colonoscopy procedures.