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Circulating microRNAs and physical activity: Impact in diabetes
1Shanghai Minyuan College, Shanghai 201210, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 3, 2025
Summary
Circulating microRNAs (ci-miRNAs) are extracellular molecules found in bodily fluids. Exercise significantly impacts ci-miRNA levels, offering potential as health and disease biomarkers.
Area of Science:
- Biochemistry
- Molecular Biology
- Exercise Physiology
Background:
- Circulating microRNAs (ci-miRNAs) are extracellular RNAs found in bodily fluids.
- ci-miRNAs function as signaling molecules and are implicated in gene regulation.
- They are investigated as potential biomarkers for various diseases like cancer and heart conditions.
Purpose of the Study:
- To provide an overview of changes in ci-miRNAs in response to exercise.
- To highlight the limited understanding of exercise's influence on ci-miRNA levels.
- To explore the potential of ci-miRNAs as exercise biomarkers.
Main Methods:
- Literature review of studies investigating ci-miRNAs and exercise.
- Analysis of existing data on ci-miRNA detection and quantification in bodily fluids.
- Synthesis of current research on ci-miRNA functions and disease association.
Main Results:
- ci-miRNAs are detectable in blood, saliva, urine, and breast milk.
- Fluctuations in ci-miRNA levels correlate with physiological and pathological states.
- Research is ongoing to understand ci-miRNA significance, biomarker viability, and functions.
Conclusions:
- ci-miRNAs show promise as biomarkers for health and disease monitoring.
- Further research is needed to elucidate the specific effects of different exercise parameters on ci-miRNAs.
- Understanding exercise-induced ci-miRNA changes can enhance their application in sports medicine and health.
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