A 3D-printed grid-like hyaluronic acid based hydrogel loaded with deferoxamine as wound dressing promotes diabetic...

The rigid inflammatory microenvironment and impaired vascular regeneration capability are two core barriers for diabetic wound healing. As hydrogels have unique 3D porous networks and hydrophilic structure, which can facilitate oxygen exchange and function as a functional delivery system for loading cells and other biomolecules, hydrogels have clinical potentials for treating diabetic wounds. Here we developed a 3D-printed grid-like hydrogel composed of hyaluronic acid-based acrylamide (HA-AM), oxidized mannan oligosaccharide (OMOS), and deferoxamine (DFO). We demonstrated that the developed hydrogel (HA-AM/OMOS@DFO) exhibited favorable swelling, reasonable degradation time, good biocompatibility and structural support strength. Moreover, the HA-AM/OMOS@DFO hydrogel exerted antioxidative effects and inflammatory regulation functions. In addition, the loaded DFO effectively promoted vascular regeneration in the wound, which facilitated the healing of chronic diabetic wounds. Findings suggested the developed material has potential for clinical application in treating diabetic wounds.