Research progress on MXenes in polysaccharide-based hemostasis and wound healing: A review

Traumatic events occur frequently in daily life, and hemostasis and infection prevention represent key challenges in trauma care. Polysaccharide-based materials (chitosan, cellulose, etc.) are widely used as hemostasis materials due to their excellent designability and biocompatibility. However, their insufficient antibacterial activity and limited hemostatic capabilities diminish their effectiveness in wound care. As emerging two-dimensional nanomaterials, MXene offers promising solutions to these limitations. With superior hydrophilicity, antibacterial properties and biocompatibility, MXene enhances the performance of polysaccharide-based hemostasis materials. This review summarizes the characteristics and synthesis methods of MXenes and outlines recent advances in MXene/polysaccharide composites for promoting wound healing by controlling bleeding and preventing infection. Additionally, we discuss the preparation methods, the mechanisms of action, and challenges in practical applications of MXene/polysaccharide composites, and propose future research directions. By integrating the advantages of MXenes and polysaccharides, we hope to provide a more effective solution for the research of polysaccharide-based hemostatic materials.