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Related Experiment Video

Updated: Jul 20, 2026

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Design and advances in antioxidant hydrogels for ROS-induced oxidative disease.

Yi Xia1, Xinyi Li1, Fan Huang1

  • 1State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.

Acta Biomaterialia
|February 3, 2025
PubMed
Summary

Antioxidant hydrogels effectively eliminate harmful reactive oxygen species (ROS) to combat oxidative stress and related diseases. This review details their design, components, and applications for conditions like wounds and osteoarthritis.

Keywords:
AntioxidantsDrug deliveryHydrogelReactive oxygen species (ROS)Wound healing

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Materials Chemistry

Background:

  • Reactive oxygen species (ROS) are vital in physiology but excessive levels cause oxidative stress, linked to acute and chronic diseases.
  • Current treatments for ROS-induced diseases face limitations, highlighting the need for effective antioxidant strategies.
  • Bioactive hydrogels offer a promising platform for localized antioxidant delivery and ROS scavenging.

Purpose of the Study:

  • To review recent advances in the design and application of antioxidant hydrogels for treating ROS-induced oxidative diseases.
  • To provide a comprehensive understanding of antioxidant components, crosslinking methods, and fabrication techniques for these hydrogels.
  • To discuss the biomedical applications of antioxidant hydrogels, focusing on diseases such as skin wounds, myocardial infarction, and osteoarthritis.

Main Methods:

  • Literature review of recent research on antioxidant hydrogels.
  • Classification and detailed description of various antioxidant components incorporated into hydrogels.
  • Summary and discussion of crosslinking methods and fabrication techniques for antioxidant hydrogels.
  • Analysis of biomedical applications, particularly in treating specific diseases and conditions.

Main Results:

  • Antioxidant hydrogels demonstrate rapid and continuous elimination of excessive ROS, improving local oxidative stress environments.
  • Diverse antioxidant components and crosslinking strategies can be employed to tailor hydrogel properties.
  • Significant potential shown in treating diseases including skin wounds, myocardial infarction, and osteoarthritis.

Conclusions:

  • Antioxidant hydrogels represent a significant advancement in managing ROS-induced oxidative stress and related pathologies.
  • Further research into design principles and applications can lead to novel therapeutic approaches for oxidative diseases.
  • This review offers insights for developing innovative antioxidant hydrogel-based therapies.