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Updated: May 29, 2025

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Oligomerization of STING and Chemical Regulatory Strategies
Xi Chen1, Shao-Hua Zhuo2, Yan-Mei Li2,3,4
1Zhili College, Tsinghua University, Beijing, 100084, P. R. China.
Abstract:
Stimulator of interferon genes (STING) plays a crucial role in innate immunity. Upon the recognition of cytosolic dsDNA, STING undergoes several structural changes, with oligomerization playing a key role in initiating a cascade of immune responses. Therefore, controlling the STING pathway by manipulating STING oligomerization is a practical strategy. This review focuses on the detailed mechanism of STING oligomerization, highlighting its decisive role. It also describes oligomerization-based strategies to regulate STING protein, such as the use of small-molecule agonists and biomacromolecules, highlighting their interaction modes and potential therapeutic applications. This knowledge may lead to the development of innovative approaches for treating cancer and immune disorders.
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