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[Effect of emotional tension on intravascular coagulation in patients with angiographically established ischemic

E I Sokolov, T P Khovanskaia, M V Baluda

    Kardiologiia
    |February 1, 1985
    PubMed

    Insights

    Simulated emotional stress (ES) worsens blood clotting in coronary patients. Stress increases thrombogenic potential, leading to more intravascular coagulation in these individuals.

    Area of Science:

    • Cardiovascular Science
    • Hemostasis Research
    • Stress Physiology

    Background:

    • The hemostatic system is crucial for blood clotting.
    • Coronary patients often exhibit pre-existing hemostatic disturbances.
    • Emotional stress can impact physiological systems.

    Purpose of the Study:

    • To investigate the impact of simulated emotional stress (ES) on hemostasis.
    • To compare the effects of ES in normal subjects versus coronary patients.
    • To identify specific hemostatic markers affected by ES in coronary patients.

    Main Methods:

    • Simulated emotional stress (ES) was administered to participants.
    • Platelet/vascular and plasma components of the hemostatic system were analyzed.
    • Key markers including cAMP/cHMP ratio, soluble fibrin, fibrinogen-fibrin degradation products (FDPs), and antithrombin III were measured.

    Main Results:

    • Coronary patients displayed pre-existing hemostatic abnormalities and a tendency towards intravascular coagulation.
    • ES significantly increased the thrombogenic potential in coronary patients.
    • Declining cAMP/cHMP ratio, increased FDPs, and reduced antithrombin III indicated enhanced intravascular coagulation post-stress.

    Conclusions:

    • Emotional stress exacerbates the pro-thrombotic state in coronary patients.
    • Hemostatic system alterations under stress highlight a heightened risk of coagulation disorders.
    • Findings suggest stress management may be important for coronary patient care.

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