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Related Concept Videos

Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Related Experiment Video

Updated: May 29, 2025

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

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[The weight-loss injection : An orthopaedic overview].

Saif Al Basri1, Wiebke K Fenske2

  • 1Allgemeine Innere Medizin, Endokrinologie und Diabetologie, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland. saif.albasri@ruhr-uni-bochum.de.

Orthopadie (Heidelberg, Germany)
|February 3, 2025
PubMed
Summary

New weight loss injections show promise for obesity in orthopaedic surgery patients, but evidence on postoperative outcomes remains mixed. Individualized care is crucial for optimal surgical results.

Keywords:
Bariatric surgeryGLP-1-RAIncretinsMorbid obesitySemaglutideTirzepatideTreatment outcome

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Area of Science:

  • Orthopaedic Surgery
  • Endocrinology
  • Pharmacology

Context:

  • Obesity is a growing challenge in orthopaedic surgery, increasing patient risk for complications.
  • Morbidly obese patients face higher risks of adverse postoperative events.
  • Incretin-based therapies (e.g., semaglutide, tirzepatide) offer potential for preoperative weight loss.

Purpose:

  • To review the current evidence on incretin-based therapies for weight reduction in orthopaedic surgery.
  • To assess the impact of these therapies on peri- and postoperative complications.
  • To highlight the need for further research on their safety and efficacy in this patient population.

Summary:

  • Evidence on incretin-based therapies' effect on postoperative outcomes is inconsistent.
  • Retrospective studies suggest rapid preoperative weight loss may increase complication risks.
  • Meta-analyses indicate potential benefits of long-term weight reduction on surgical outcomes.

Impact:

  • Current evidence is insufficient to fully establish the safety and efficacy of these drugs in orthopaedic surgery.
  • An individualized, multidisciplinary approach is essential for optimizing surgical outcomes.
  • Further high-quality studies are needed to guide clinical practice.