Postacute COVID-19 fatigue, dyspnea and reduced activity in children and adolescents

This study aimed to quantify fatigue, dyspnea, and physical activity and identify associated factors in children and adolescents with postacute COVID-19 syndrome.

A prospective cohort study included 74 participants aged 6-18 years with postacute COVID-19 symptoms and 120 age- and sex-matched controls without SARS-CoV-2 antibodies. Participants completed questionnaires assessing fatigue, dyspnea, and physical activity and underwent pulmonary function tests.

Children with postacute COVID-19 syndrome reported significantly greater fatigue (parent-rated scores: mean 67.9 vs. 82.4, p < 0.001; child-rated scores: 73.7 vs. 83.0, p < 0.001), increased dyspnea (mMRC grades 3-4: 10.9% vs. 4.1%, p = 0.001), and lower physical activity (median 787.8 vs. 1658.5 MET*min/week, p < 0.001) than controls. They also had a higher prevalence of mixed (8.1% vs. 1.7%, p = 0.029) and restrictive lung disease (29.7% vs. 10.8%, p = 0.001). Older age and COVID-19 were identified as risk factors for fatigue and reduced activity. Fatigue correlated with reduced physical activity but not with pulmonary function.

Children and adolescents with postacute COVID-19 syndrome, particularly older individuals, experience greater fatigue and reduced physical activity than controls. These findings highlight the importance of quantifying postacute COVID-19 symptoms and their associations with physiological assessments.

This prospective, age- and sex-matched cohort study revealed that children and adolescents with postacute COVID-19 syndrome perceived higher fatigue levels, had higher dyspnea scores, had a greater prevalence of mixed lung and restrictive lung disease, and exhibited less physical activity than their control counterparts. Fatigue correlated with reduced physical activity but was not consistently correlated with pulmonary function test results. This study highlights the importance of quantifying postacute COVID-19 symptoms and exploring the associations between individual symptoms and the impact of coronavirus infection on various systems, including the neurological, musculoskeletal, cardiopulmonary, and immune systems.