FireVoxel: Interactive Software for Multi-Modality Analysis of Dynamic Medical Images

This article provides an overview of the FireVoxel software for quantitative analysis of medical images and its applications in the field. We describe FireVoxel's user interface, multi-layer design, dynamic parametric models, and several turn-key workflows. Additionally, we discuss its application in recent imaging projects. We outline basic image analysis tools such as segmentation, non-uniformity correction, and coregistration through a pictorial overview, with a focus on deformable coregistration and motion correction. Several example workflows and image-based dynamic modeling are also highlighted. Furthermore, we analyze peer-reviewed studies that utilized FireVoxel for image processing, categorizing published papers based on body structures/organs, image processing methods, and imaging modalities. For comparison, we searched the Ovid MEDLINE database to assess the general use of medical image analysis software. FireVoxel is used by over 3000 users worldwide, with 528 articles, including 413 in English, published in the past 15 years. MRI is the most commonly used imaging modality (78.2%), followed by CT (14.5%) and PET (7.3%). The most frequently used methods are dynamic modeling, segmentation, texture analysis, and coregistration. FireVoxel is commonly used in abdominal and genitourinary imaging studies, where it appears to fill a niche due to the lack of alternative software. The search of the Ovid MEDLINE suggests that quantitative medical imaging studies, on the other hand, focus on the brain and cardiovascular system. FireVoxel offers an effective set of quantitative tools, particularly for abdominal and genitourinary imaging, likely due to its ability to manage patient motion and correct for MR artifacts. The software is especially valuable for processing dynamic studies. The steady increase in publications utilizing FireVoxel reflects growing interest in this software and its relevance for image-based research.