SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer
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View abstract on PubMed
Summary
This summary is machine-generated.P-selectin (SELP) expressed in cervical cancer endothelial cells enhances anti-cancer immunity and improves radiotherapy outcomes. Targeting SELP+ endothelial cells and CD8+ T cell interactions may overcome treatment resistance.
Area Of Science
- Oncology
- Immunology
- Cell Biology
Background
- P-selectin (SELP) in tumor cells is linked to cancer progression and treatment resistance.
- SELP expression in cervical cancer (CC) endothelial cells may influence anti-cancer immunity and radiotherapy response.
- Mechanisms of SELP's role in CC immunity and radiotherapy remain unclear.
Purpose Of The Study
- Investigate the role of SELP in tumor endothelial cells (TECs) in CC radiotherapy response.
- Elucidate the mechanisms by which SELP influences anti-cancer immunity.
- Determine the association between SELP expression and patient survival outcomes.
Main Methods
- Analysis of tumor tissue samples from 205 CC patients undergoing radiotherapy.
- Single-cell RNA sequencing (scRNA-seq) of 42,159 cells from eight CC patients.
- Bulk RNA sequencing of 187 radiotherapy-treated CC patients.
Main Results
- Elevated SELP expression in TECs correlated with improved radiotherapy survival outcomes.
- SELPhigh group showed enriched immune pathways and reduced proliferation/angiogenesis.
- Increased CD8+ T cell infiltration and ACKR1 expression were observed in SELPhigh tumors.
- SELP+ TECs and CD8+ T cells interact via the ACKR1-CCL5 axis, enhancing radiotherapy efficacy.
Conclusions
- SELP+ TECs play a crucial role in enhancing CC radiotherapy response through interaction with CD8+ T cells.
- The ACKR1-CCL5 pathway mediates the crosstalk between SELP+ TECs and CD8+ T cells.
- Targeting this SELP+ TEC:CD8+ T cell crosstalk offers potential therapeutic strategies against treatment resistance in CC.
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