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The Emerging Role of Long Non-coding RNA 01296 in Human Malignancies

Lei Luo1, Fan Yang1, Xiaoping Fu1

  • 1Department of Health Management Center, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430070, P.R. China.

Current Molecular Medicine
|February 4, 2025
PubMed

Insights

Long non-coding RNA 01296 (LINC01296) is implicated in cancer progression. This review highlights LINC01296 as a potential biomarker and therapeutic target for various human malignancies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators in biological processes.
  • Dysregulation of lncRNAs, including LINC01296, is associated with cancer development and progression.
  • LINC01296 is frequently overexpressed in human cancers, correlating with disease advancement.

Purpose of the Study:

  • To comprehensively review the role and mechanisms of LINC01296 in human cancers.
  • To explore the clinical significance of LINC01296 as a biomarker and therapeutic target.
  • To summarize recent advancements in understanding LINC01296's function in malignant tumors.

Main Methods:

  • Literature review of studies investigating LINC01296 in cancer.
  • Analysis of LINC01296 expression levels and their correlation with cancer prognosis.
  • Examination of LINC01296's molecular mechanisms, including its role as a competitive endogenous RNA (ceRNA).

Main Results:

  • LINC01296 dysregulation influences cancer cell proliferation, apoptosis, invasion, metastasis, and cell cycle.
  • LINC01296 acts as a ceRNA, regulating target genes and signaling pathways critical for cancer.
  • Elevated LINC01296 levels are linked to poorer prognosis in various cancers.

Conclusions:

  • LINC01296 plays a significant role in the pathogenesis and progression of human cancers.
  • LINC01296 demonstrates potential as a reliable prognostic biomarker for cancer patients.
  • LINC01296 represents a promising therapeutic target for novel cancer interventions.
Keywords:
CancerLINC01296long non-coding RNAmolecular mechanismsprognostic biomarker.therapeutic target

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