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Novel Therapeutic Approaches Emerging in the Field of Onychomycosis
Gurisha Garg1, Raj Kamal1, Sonakshi Garg1
1Department of Pharmaceutical Quality Assurance, ISF College of Pharmacy, GT Road, Moga, Punjab, 142001, India.
Abstract:
Onychomycosis is regarded as one of the most common and least concerned fungal problems. Although various treatment approaches have been well-established, still treatment strategies suffer from certain drawbacks, so there is a need to discuss novel therapies that could ultimately eliminate all the conventional barriers. It is a nail infection that begins in the toenail and spreads, causing significant negative impacts on patients' quality of life. The purpose of this work was to highlight the limitations of conventional treatments and shed light on novel therapies for managing onychomycosis. A comprehensive review on existing topical and systemic therapies was conducted, with a focus on their drawbacks, such as recurrence and lower efficacy. This review aimed to explore the increasing prevalence of onychomycosis, which poses a serious health issue; however, the advent of nanobased drug delivery systems offers hope for more effective management of this prevalent disease. These systems could potentially overcome the limitations of conventional treatments, thereby improving patient outcomes.
Insights
Onychomycosis, a common nail fungal infection, often has treatments with drawbacks like recurrence. Nanobased drug delivery systems show promise for overcoming these limitations and improving patient outcomes for fungal nail infections.
Area of Science:
- Mycology
- Dermatology
- Nanotechnology
Background:
- Onychomycosis is a prevalent fungal nail infection impacting quality of life.
- Conventional treatments for onychomycosis face challenges including recurrence and limited efficacy.
Purpose of the Study:
- To review the limitations of current onychomycosis treatments.
- To explore novel therapeutic strategies for managing onychomycosis.
Main Methods:
- A comprehensive literature review of existing topical and systemic therapies for onychomycosis.
- Analysis of drawbacks associated with conventional treatment modalities.
Main Results:
- Conventional therapies for onychomycosis demonstrate significant limitations, including high recurrence rates and suboptimal efficacy.
- Nanobased drug delivery systems present a promising avenue for enhanced onychomycosis management.
Conclusions:
- Nanobased systems offer a potential solution to overcome the barriers associated with traditional onychomycosis treatments.
- Advancements in nanodelivery systems could significantly improve patient outcomes for this widespread fungal infection.
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