Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Frequency Pseudo-Cohort Threshold Change and Severity-Dependent Sex Disparity in 4-kHz Audiometric Notching in Korean Adults.

Clinical and experimental otorhinolaryngology·2026
Same author

Clinical Practice Guideline for the Diagnosis and Management of Tinnitus in Korea.

Clinical and experimental otorhinolaryngology·2026
Same author

The impact of climate and environmental factors on the incidence of Bell's palsy: a nationwide population study.

Acta oto-laryngologica·2026
Same author

Values and Preferences of Korean Patients With Facial Palsy: A Cross-Sectional Survey.

Journal of Korean medical science·2026
Same author

3D computed tomography airway geometry for predicting bronchoscopic accessibility in peripheral pulmonary nodules: a prospective study.

Translational lung cancer research·2026
Same author

Label-Free Lung MRI Segmentation via Misalignment-Aware Diffusion Translation.

Journal of imaging informatics in medicine·2026

Related Experiment Video

Updated: May 29, 2025

Acellular and Cellular Lung Model to Study Tumor Metastasis
08:31

Acellular and Cellular Lung Model to Study Tumor Metastasis

Published on: August 19, 2018

7.5K

Tracing Metastatic Evolutionary Patterns in Lung Adenocarcinoma: Prognostic Dissection Based on a Multi-state Model.

Geewon Lee1,2, Yang-Jin Kim3, Insuk Sohn4

  • 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Cancer Research and Treatment
|February 4, 2025
PubMed
Summary

Clinical and pathological factors significantly impact lung adenocarcinoma recurrence after surgery. Pathological lymph node status is a key risk factor for metastasis, influencing patient prognosis and survival outcomes.

Keywords:
Multi-state modelNon-small cell lung carcinomaTransition intensity

More Related Videos

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

976
Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

12.5K

Related Experiment Videos

Last Updated: May 29, 2025

Acellular and Cellular Lung Model to Study Tumor Metastasis
08:31

Acellular and Cellular Lung Model to Study Tumor Metastasis

Published on: August 19, 2018

7.5K
Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

976
Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

12.5K

Area of Science:

  • Oncology
  • Medical Statistics

Background:

  • Lung adenocarcinoma recurrence after surgery presents diverse clinical scenarios.
  • Understanding recurrence pathways is crucial for effective patient management.

Purpose of the Study:

  • To investigate the influence of clinical and pathological factors on tumor recurrence, death, and prognosis.
  • To analyze various metastasizing pathways in lung adenocarcinoma post-surgery.

Main Methods:

  • Utilized a multi-state model (MSM) on data from 335 lung adenocarcinoma patients with over 10 years of follow-up.
  • Defined disease states including operation, local recurrence, metastasis, concurrent local recurrence with metastasis, and death.
  • Identified 8 distinct transitions representing tumor progression pathways.

Main Results:

  • Approximately 50% of patients experienced recurrence post-surgery.
  • Pathological lymph node status was a significant risk factor for metastasis (p=0.001) and concurrent local recurrence with metastasis (p=0.001).
  • Different clinical and pathological factors were associated with distinct recurrence transitions.

Conclusions:

  • Lung adenocarcinoma recurrence pathways and associated risk factors vary significantly post-surgery.
  • The multi-state model aids in predicting intervention timing and type for improved survival.
  • Prognosis differs across various recurrence pathways, highlighting the need for tailored treatment strategies.