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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

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Published on: August 5, 2022

Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer.

Minzhen Li^1,2, Zhili Xia³, Ruiyu Wang^1,2

¹Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Frontiers in Oncology

|February 4, 2025

Summary

This summary is machine-generated.

DNA methylation biomarkers show promise for early endometrial cancer (EC) detection and risk assessment. This review highlights recent findings on their use in diagnosis, prognosis, and personalized treatment strategies for EC patients.

Keywords:

DNA methylation early diagnostic biomarker endometrial cancer fertility preservation prognosis risk assessment therapy resistance

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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

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Methyl-binding DNA capture Sequencing for Patient Tissues

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

Gynecology
Oncology
Epigenetics

Background:

Endometrial cancer (EC) is a common gynecologic malignancy with poor outcomes in advanced stages.
Epigenetic alterations, specifically DNA methylation, are crucial in EC development and progression.
Current diagnostic and prognostic tools for EC require improvement, especially for young women.

Purpose of the Study:

To comprehensively review recent advances in DNA methylation-based biomarkers for early endometrial cancer diagnosis.
To explore the role of DNA methylation in EC risk assessment, prognosis, and treatment response.
To summarize current research on DNA methylation in EC treatment resistance and drug development.

Main Methods:

Literature review focusing on studies published within the last two years.
Analysis of DNA methylation biomarkers across various sample types: cervical scraping, vaginal fluid, urine, blood, and tissue.
Synthesis of findings related to EC carcinogenesis risk, fertility preservation, prognosis, and treatment resistance.

Main Results:

DNA methylation patterns are emerging as sensitive and specific biomarkers for early EC detection across different sample sources.
Methylation analysis aids in assessing EC risk, guiding fertility-sparing treatments, and predicting patient prognosis.
Emerging evidence links DNA methylation to resistance against first-line EC treatments, suggesting therapeutic targets.

Conclusions:

DNA methylation biomarkers offer significant potential for improving early diagnosis, risk stratification, and personalized management of endometrial cancer.
Further research into DNA methylation can lead to novel therapeutic strategies and improved patient outcomes in EC.
The integration of DNA methylation analysis into clinical practice holds promise for advancing endometrial cancer care.