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Updated: May 29, 2025

Author Spotlight: Assessment of Environmental and Drug-Induced Behavioral Changes in Adult Zebrafish
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ZFIN updates to support zebrafish environmental exposure data.

Yvonne M Bradford1, Ceri E Van Slyke1, Jonathan B Muyskens1

  • 1The Institute of Neuroscience, University of Oregon, 5291 University of Oregon, Eugene, OR 97403-5291, USA.

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|February 4, 2025
PubMed
Summary
This summary is machine-generated.

The Zebrafish Information Network (ZFIN) now better supports toxicology research by incorporating chemical exposure data. This enhancement allows researchers to more easily find and analyze chemical-linked phenotypes and disease models in zebrafish.

Keywords:
danio rerioZFINenvironmental exposureexpressionhuman disease modelmodel organism databasephenotypezebrafish

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Area of Science:

  • * Developmental biology and toxicology research.
  • * Utilizing zebrafish (Danio rerio) as a model organism.

Background:

  • * Zebrafish Information Network (ZFIN) is a primary resource for zebrafish genetic, genomic, and phenotypic data.
  • * Zebrafish are increasingly used to study environmental exposures, toxicity, and gene-chemical interactions.
  • * Existing database resources for zebrafish toxicology are limited.

Purpose of the Study:

  • * To enhance ZFIN's functionality for incorporating and presenting toxicology data.
  • * To improve the discoverability of chemical exposure-related research in zebrafish.
  • * To detail how ZFIN displays and allows searching of chemical exposure experimental data.

Main Methods:

  • * Expanded ZFIN's data curation to include toxicology information.
  • * Annotated chemicals using Chemical Entities of Biological Interest Ontology (ChEBI).
  • * Utilized Zebrafish Experimental Conditions Ontology (ZECO) for exposure routes and conditions.
  • * Integrated experimental condition data into gene expression, phenotype, and disease model annotations.

Main Results:

  • * ZFIN now better captures and displays data on chemical exposures in zebrafish.
  • * Chemical term pages provide detailed information on chemical exposures.
  • * Enhanced search and download capabilities for chemical exposure data are available.
  • * Phenotypes and human disease models linked to chemicals are more efficiently searchable.

Conclusions:

  • * ZFIN's expanded functionality improves zebrafish toxicology research.
  • * The integrated data facilitates a deeper understanding of gene-chemical interactions and environmental exposure effects.
  • * Researchers can now more effectively leverage ZFIN for chemical exposure studies in zebrafish.