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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: May 29, 2025

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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Chimeric Antigen Receptor Cells Solid Tumor Immunotherapy Assisted by Biomaterials Tools.

Yujie Song1, Yifan Wang1, Jianping Man1

  • 1State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.

ACS Applied Materials & Interfaces
|February 4, 2025
PubMed
Summary

Chimeric antigen receptor (CAR) immune cell therapies show promise for solid tumors. Biomaterials can enhance CAR-T, CAR-NK, and CAR-M cell efficacy by overcoming tumor microenvironment challenges for improved cancer treatment.

Keywords:
CAR immune cellbiomaterialsdelivery strategiesimmunotherapysolid tumors

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Area of Science:

  • Oncology
  • Immunotherapy
  • Nanobiotechnology

Background:

  • Chimeric antigen receptor (CAR) immune cell therapies have transformed hematological cancer treatment.
  • Efficacy against solid tumors is limited by dense stromal barriers and immunosuppressive tumor microenvironments.
  • Advancements in nanobiotechnology offer new strategies to enhance CAR cell therapy for solid tumors.

Purpose of the Study:

  • To review CAR-T, CAR-NK, and CAR-M cell therapy structures, mechanisms, and potential for solid tumors.
  • To analyze challenges faced by CAR cell therapies in solid tumor treatment.
  • To explore the role of biomaterials in optimizing CAR cell therapy efficacy.

Main Methods:

  • Review of CAR cell therapy types (CAR-T, CAR-NK, CAR-M) and their mechanisms.
  • Analysis of solid tumor microenvironment challenges.
  • Exploration of biomaterial applications for enhancing CAR cell therapy.

Main Results:

  • CAR-T, CAR-NK, and CAR-M cells have potential but face significant hurdles in solid tumors.
  • Biomaterials can improve the tumor microenvironment, control CAR cell delivery, and enhance infiltration and efficacy.
  • Combining biomaterials with CAR cell therapy offers a promising strategy for solid tumor treatment.

Conclusions:

  • Biomaterial-enhanced CAR cell therapy presents a viable strategy for overcoming solid tumor treatment challenges.
  • Further research and development are needed for effective clinical application.
  • This review provides theoretical perspectives and practical guidance for future solid tumor treatment strategies.