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Related Experiment Video

Updated: May 29, 2025

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Evolutionary-Distinct Viral Proteins Subvert Rice Broad-Spectrum Antiviral Immunity Mediated by the RAV15-MYC2

Hehong Zhang1, Chaorui Huang1, Chenfei Gao1

  • 1State Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Zhejiang Key Laboratory of Green Plant Protection, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 4, 2025
PubMed
Summary
This summary is machine-generated.

Distinct rice viruses share a common strategy: they target the OsRAV15 transcription factor to suppress jasmonic acid (JA)-mediated antiviral immunity, hindering plant defenses.

Keywords:
OsRAV15 transcription factorantiviral immunityjasmonic acidrice virusesviral proteins

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Area of Science:

  • Plant pathology
  • Molecular biology
  • Virology

Background:

  • Plant viruses utilize diverse strategies for infection, often leading to abnormal plant development.
  • The shared pathogenicity mechanisms across different plant viruses remain underexplored.

Purpose of the Study:

  • To investigate a common virulence strategy employed by distinct plant viruses.
  • To identify viral targets involved in suppressing plant antiviral immunity.

Main Methods:

  • Investigated the role of the RAV-type transcription factor OsRAV15 in plant antiviral defense.
  • Analyzed the interaction between OsRAV15 and jasmonic acid (JA) signaling components (OsMYC2-OsJAZ complex).
  • Examined how viral proteins from diverse rice viruses disrupt this interaction.

Main Results:

  • OsRAV15 activates broad-spectrum antiviral immunity via JA signaling by interacting with OsMYC2-OsJAZ.
  • Distinct viral proteins from various rice viruses target and disrupt the OsRAV15-OsMYC2 complex.
  • This disruption attenuates JA signaling, facilitating viral infection.

Conclusions:

  • Reveals a conserved viral counter-defense strategy targeting the OsRAV15-OsMYC2 module.
  • Highlights the crucial role of the OsRAV15-OsMYC2 complex in regulating JA-mediated antiviral defense in rice.
  • Identifies a common mechanism by which diverse viruses overcome plant immunity.