Related Experiment Video
Updated: May 5, 2026
In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
Published on: May 11, 2020
Hidden threats: Brucellosis diagnosis and co-infection patterns in Crimean-Congo Hemorrhagic Fever suspects
Murtaza Öz1, Fatih Çubuk2, Yasemin Çakır Kıymaz3
1Department of Infectious Diseases and Clinical Microbiology, Sivas Numune Hospital, Sivas, Türkiye.
Insights
Brucellosis affects 3.2% of patients with Crimean-Congo Hemorrhagic Fever (CCHF). Given symptom overlap, brucellosis should be considered in CCHF differential diagnoses.
Area of Science:
- Infectious Diseases
- Epidemiology
- Clinical Medicine
Background:
- Crimean-Congo Hemorrhagic Fever (CCHF) and brucellosis are significant infectious diseases.
- Both conditions share overlapping symptoms and risk factors, complicating diagnosis.
Purpose of the Study:
- To determine the prevalence of brucellosis in patients initially diagnosed with CCHF.
- To highlight the importance of considering brucellosis in the differential diagnosis of CCHF.
Main Methods:
- Retrospective evaluation of 1231 patients.
- Included 14 patients with CCHF and brucellosis coinfection and 25 with brucellosis alone.
- Statistical analysis using Mann-Whitney U and Fisher's exact tests.
Main Results:
- Brucellosis was identified in 3.2% of patients with a preliminary CCHF diagnosis.
- Co-infected patients exhibited shorter hospital admission times, increased tick exposure, and more frequent headaches.
- Elevated creatine kinase and lower lymphocyte and fibrinogen levels were noted in the co-infected group.
Conclusions:
- A 3.2% brucellosis rate was found in CCHF patients.
- Brucellosis should be considered in the differential diagnosis of CCHF due to symptom and risk factor similarities.
- Concurrent brucellosis evaluation is crucial for patients diagnosed with CCHF.
Purpose:
This study aims to investigate the frequency of brucellosis in patients with Crimean-Congo Hemorrhagic Fever (CCHF).
Method:
In this study, 1231 patients were evaluated retrospectively, including 14 patients with CCHF and brucellosis coinfection and 25 patients with brucellosis alone. Statistical methods such as the Mann-Whitney U test and Fisher's exact test were used.
Result:
Of the patients with a preliminary diagnosis of Crimean-Congo Hemorrhagic Fever (CCHF), 3.2% were found to have brucellosis. In the group co-infected with brucellosis and CCHF, the time to hospital admission was shorter. Additionally, tick exposure and headache were observed more frequently in this group. Creatine kinase levels were found to be higher in the co-infected group, while lymphocyte counts and fibrinogen levels were lower compared to the group with brucellosis alone.
Conclusion:
Our study revealed a 3.2% rate of brucellosis in patients with a preliminary diagnosis of CCHF. Due to the similarity of symptoms and common risk factors, the differential diagnosis of brucellosis should be considered in patients diagnosed with CCHF. Additionally, the possibility of brucellosis coexisting with CCHF should always be considered. Even in patients diagnosed with CCHF, an evaluation for brucellosis must be conducted.
More Related Videos
Related Concept Videos
01:28Infectious Diseases and Their Occurrence
01:23Investigation of Disease Outbreaks