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Updated: May 29, 2025
06:23
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
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Coagulation Abnormalities in Chronic Liver Disease
Massimo Franchini1, Pier Mannuccio Mannucci2
1Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova, Italy.
Seminars in Thrombosis and Hemostasis
|February 4, 2025
Summary
Chronic liver disease disrupts hemostasis, causing unpredictable bleeding and clotting risks. Understanding these hemostatic derangements is key for managing patients with liver cirrhosis.
Area of Science:
- Hepatology and Hematology
Background:
- Chronic liver disease (CLD) is a global health concern with complex pathophysiology.
- CLD significantly impacts the hemostatic system, affecting both primary and secondary hemostasis.
Purpose of the Study:
- To review recent advances in understanding hemostatic derangements in CLD.
- To focus on the clinical implications and management strategies for these hemostatic changes.
Main Methods:
- This is a narrative review.
- The review synthesizes current literature on pathophysiology, clinical implications, and management.
Main Results:
- CLD causes heterogeneous hemostatic alterations, including prohemorrhagic factors (e.g., decreased coagulation factors, thrombocytopenia) and prothrombotic factors (e.g., reduced natural anticoagulants).
- This imbalance leads to unpredictable hemorrhagic and venous thromboembolic events in patients with liver cirrhosis.
Conclusions:
- The complex hemostatic profile in CLD presents significant clinical challenges.
- Effective management requires a thorough understanding of the pathophysiology of bleeding and clotting disorders in liver cirrhosis.
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