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Updated: Jun 6, 2026

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
Published on: June 10, 2022
Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model
Yeqi Li1, Suresh Ambati2, Richard B Meagher3
1Department of Microbiology, University of Georgia, Athens, GA, 30602, USA.
Abstract:
Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Remarkably, when coupled with capsule adjuvant, vaccination with CDA1-LNPs protected the vast majority of mice from the otherwise lethal cryptococcosis. These results support the promise of mRNA-LNP vaccines against fungal diseases.

