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Refining partial gland ablation for localised prostate cancer: the FALCON project
Lara Rodriguez-Sanchez1, Xavier Cathelineau1,2, Theo M de Reijke3
1Department of Urology, Institut Mutualiste Montsouris, Paris, France.
BJU International
|February 5, 2025
Summary
This study established consensus on focal therapy (FT) for localised prostate cancer (PCa) among international experts. It identified key areas for future research to improve FT application and patient outcomes.
Area of Science:
- Urology
- Oncology
- Medical Consensus
Background:
- Focal therapy (FT) is an emerging treatment for localised prostate cancer (PCa).
- Previous consensus statements were limited in scope and participant diversity.
- There is a need for updated guidance on various aspects of FT application.
Purpose of the Study:
- To develop a contemporary international consensus statement on FT for localised PCa.
- To address limitations of prior statements by including diverse physician perspectives.
- To provide direction on currently undefined aspects of FT.
Main Methods:
- The FocAL therapy CONsensus (FALCON) project utilized a Modified Delphi method.
- A 154-item online survey was followed by three rounds of consensus building.
- An in-person expert meeting finalized areas lacking consensus (70% agreement threshold).
Main Results:
- 148 of 246 initial participants completed the Delphi study.
- Consensus was reached on 57 additional items during the in-person meeting.
- Consensus was not achieved on 12 specific items, highlighting knowledge gaps.
Conclusions:
- The FALCON project achieved significant consensus on the approach to FT for localised PCa.
- The study identified critical areas requiring further research to advance FT.
- This consensus provides a contemporary framework for FT in prostate cancer management.
