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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

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Published on: August 19, 2012

UV/Ozone-Assisted Covalent Bioconjugation on Graphene Tapes.

Feng Jiang^1,2, Lin Qi^1,3, Stephen Chengxi Li¹

¹Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Langmuir : the ACS Journal of Surfaces and Colloids

|February 5, 2025

Summary

This summary is machine-generated.

Ultraviolet/ozone treatment activates graphene tape for enhanced biomolecule conjugation. This method enables high-performance electroactive biofunctional devices with improved stability and efficiency.

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Area of Science:

Materials Science
Biotechnology
Electrochemistry

Background:

Graphene oxide (GO) offers advantages for biological applications due to its solubility and functional groups for biomolecule conjugation.
Developing versatile functional devices requires stable covalent conjugation of biomolecules onto graphene-based substrates.

Purpose of the Study:

To explore ultraviolet/ozone (UV/O3) treatment for activating graphene tape substrates.
To enhance the bioconjugation capabilities of graphene-based materials for biofunctional devices.

Main Methods:

Drop-casting graphene nanoplatelets onto conductive carbon tapes.
Activating graphene-carbon tape using ultraviolet/ozone (UV/O3) treatment.
Characterizing surface modifications using Fourier transform infrared spectroscopy (FTIR), wetting, and X-ray photoelectron spectroscopy (XPS).
Covalently immobilizing amino-ferrocene and glucose oxidase.

Main Results:

UV/O3 treatment successfully generated high-density oxygen-containing functional groups on graphene-carbon tape.
Surface functionalization minimally impacted conductivity and electrochemical activity.
Achieved high surface density of immobilized amino-ferrocene (over 8.0 × 10^-9 mol/cm^2).
Demonstrated highly efficient conjugation and excellent catalytic activity of immobilized glucose oxidase.

Conclusions:

UV/O3-activated graphene tape exhibits excellent bioconjugation capabilities.
This method provides a convenient approach for fabricating high-performance electroactive biofunctional devices.
The functionalized graphene tape holds significant potential for advanced biosensing and bioelectronic applications.