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The Role of Small Extracellular Vesicles in Retinoblastoma Development and Progression

Jyothi Attem1, Geeta K Vemuganti1

  • 1School of Medical Sciences, Science Complex, University of Hyderabad, Hyderabad, India.

Current Eye Research
|February 5, 2025
PubMed

Insights

Extracellular vesicles (EVs) are key players in cancer progression and offer therapeutic potential. This review details small EVs (sEVs) roles in retinoblastoma (RB) and their clinical translation challenges.

Area of Science:

  • Oncology
  • Cell Biology
  • Ophthalmology

Background:

  • Extracellular vesicles (EVs) are increasingly recognized for their roles in cancer progression.
  • EVs act as natural delivery vehicles, influencing cell functions.
  • Small EVs (sEVs) are particularly important in tumor biology.

Purpose of the Study:

  • To review the mechanistic roles of sEVs in retinoblastoma (RB), a common childhood intraocular malignancy.
  • To explore the therapeutic potential of sEVs in RB as biomarkers and drug delivery vehicles.
  • To address challenges in translating sEV-based technologies for clinical use.

Main Methods:

  • Comprehensive literature review of existing research on EVs and RB.
  • Analysis of mechanistic insights into sEV functions in retinoblastoma.
  • Evaluation of current and future therapeutic applications of sEVs.

Main Results:

  • sEVs play significant roles in the progression of retinoblastoma.
  • sEVs show promise as biomarkers for early detection and monitoring of RB.
  • sEVs can be engineered for targeted delivery of therapeutic agents to retinoblastoma cells.

Conclusions:

  • Understanding sEV mechanisms in RB is crucial for developing novel therapies.
  • sEVs offer a promising avenue for targeted therapy and biomarkers in retinoblastoma.
  • Overcoming challenges in sEV production, characterization, and clinical translation is essential for realizing their full potential.
Keywords:
Retinoblastomaextracellular vesiclesimmune responsetumor microenvironmenttumor progression

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