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Related Experiment Video

Updated: May 6, 2026

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

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Imaging in Pachychoroid Disease

Sibel Demirel¹, Audrey Yan², Nicola Valsecchi³

¹Ankara University Faculty of Medicine, Vehbi Koç Eye Hospital, Department of Ophthalmology, Ankara, Türkiye

Turkish Journal of Ophthalmology

|February 5, 2025

Summary

Pachychoroid diseases involve increased choroidal thickness and vascular changes. Advanced imaging like OCTA aids in understanding these conditions and identifying choroidal neovascularization (CNV).

Keywords:

Pachychoroid disease imaging indocyanine green angiography optic coherence tomography angiography scleral thickness optic coherence tomography

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Published on: May 26, 2023

Area of Science:

Ophthalmology
Medical Imaging
Pathology

Background:

Pachychoroid describes increased choroidal thickness, often with large choroidal vessel dilation.
This can compress choriocapillaris and Sattler's layer, leading to various pathological findings.
Pachychoroid spectrum diseases share common choroidal morphological characteristics.

Purpose of the Study:

To define the morphological characteristics of the pachychoroid spectrum of diseases.
To review recent advancements in imaging modalities for understanding pachychoroid conditions.

Main Methods:

Review of current literature and imaging techniques.
Analysis of findings from widefield indocyanine green angiography (WF-ICGA) and optical coherence tomography angiography (OCTA).
Examination of scleral thickness measurements using ultrasound biomicroscopy and anterior segment OCT.

Main Results:

WF-ICGA identified peripheral retinal venous outflow congestion in pachychoroid diseases.
Thicker anterior sclera may contribute to choroidal congestion and disease pathogenesis.
OCTA demonstrates superior sensitivity and specificity for detecting choroidal neovascularization (CNV).

Conclusions:

Advanced imaging significantly enhances the understanding of pachychoroid diseases.
Morphological definition aids in diagnosis and potentially guides future therapeutic strategies.
Pachychoroid spectrum diseases present with distinct choroidal and scleral alterations.