Biomedical Applications of Metal-Organic Frameworks Revisited.

Area of Science:

• Materials Science
• Biomedical Engineering
• Nanotechnology

Background:

• Metal-organic frameworks (MOFs) are increasingly recognized as superior alternatives to traditional porous materials.
• Biomedical applications of MOFs have expanded significantly over the past decade, especially for drug storage.
• A rapid growth in MOF diversity and applications across various biomedical fields has been observed since 2011.

Purpose of the Study:

• To review diverse biomedical applications of MOFs, focusing on recent experimental and computational advancements.
• To explore MOF applications in drug storage and delivery, bioimaging, and biosensing.
• To highlight the potential of MOFs in advanced therapeutics for cancer and neurological diseases.

Main Methods:

• Literature review of experimental and computational studies on MOFs in biomedical applications.
• Analysis of molecular interactions between MOFs and biological systems.
• Discussion of opportunities and challenges in the field.

Main Results:

• MOFs are pivotal in regenerative medicine, medical imaging, and diagnostics.
• Integration of molecular modeling and data science accelerates MOF development for biomedical use.
• MOFs demonstrate potential in advanced therapeutics for cancer and neurological diseases.

Conclusions:

• MOFs offer significant potential for advanced therapeutics and diagnostics.
• Understanding MOF-biological system interactions is key to unlocking their full potential.
• Continued research in MOFs promises breakthroughs in treating complex diseases.