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Elevated plasma trimethyllysine is associated with incident atrial fibrillation
Mads M Svenningsson1,2, Gard Ft Svingen1, Per M Ueland3
1Haukeland University Hospital, Department of Heart Disease, Bergen, Norway.
American Journal of Preventive Cardiology
|February 5, 2025
Summary
Higher levels of trimethyllysine (TML) are linked to new cases of atrial fibrillation (AF). This finding improves risk prediction for AF in community-dwelling adults.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Epigenetics
Background:
- Trimethyllysine (TML) is a methylated amino acid linked to epigenetic regulation.
- TML is a precursor to trimethylamine-N-oxide (TMAO), a metabolite associated with cardiovascular disease risk.
- Previous studies linked TML to atherosclerosis, myocardial infarction, and prevalent atrial fibrillation (AF).
Purpose of the Study:
- To investigate the association between circulating TML and the incidence of AF in a large community-based cohort.
- To determine if TML improves risk classification for new-onset AF.
Main Methods:
- Utilized data from national health registries to obtain AF information.
- Employed logistic regression to explore risk associations between TML and incident AF.
- Calculated improvements in risk reclassification using continuous net reclassification index (NRI) and ROC-AUC.
Main Results:
- Included 3117 participants at baseline, with 492 (15.8%) developing AF during follow-up (median 10.8 years).
- Higher plasma TML levels were significantly associated with incident AF (OR 1.30; P < 0.01).
- TML demonstrated significant improvements in risk reclassification (NRI > 0: 0.24; ROC-AUC: 0.013).
Conclusions:
- Circulating TML is associated with new-onset AF in a large community-dwelling adult cohort.
- TML improves the risk classification of incident AF.
- Further research is warranted to explore the relationship between TML and cardiac arrhythmias.
