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Complex Clinical Interplay: A Case Report of Systemic Lupus Erythematosus Coexisting With Type II Cryoglobulinemia
Munsef Barakat1, Madison Ladines2, Salem Vilayet1
1Nephrology, Medical University of South Carolina, Charleston, USA.
Abstract:
Systemic lupus erythematosus (SLE) is a multi-faceted autoimmune disease with diverse clinical manifestations, often diagnosed through specific immunological markers. Another noteworthy immunological phenomenon associated with SLE is cryoglobulinemia (CG), characterized by circulating immunoglobulins that precipitate at lower temperatures. Although the overlap of SLE and CG is documented, its precise prevalence remains elusive. This paper presents a unique case of a patient diagnosed with lupus cryoglobulinemic glomerulonephritis through biopsy. The patient attained full remission after an initial induction using the Eurolupus protocol complemented with plasmapheresis, with subsequent maintenance therapy managed via rituximab.
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