Related Experiment Video
Updated: May 29, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Platinum(ii) complexes of aryl guanidine-like derivatives as potential anticancer agents: between coordination and
Patrick O'Sullivan1, Viola Previtali1, Brendan Twamley1
1School of Chemistry, Trinity College Dublin 152-160 Pearse Street Dublin 2 Ireland rozasi@tcd.ie +353 1 896 3731.
Abstract:
The preparation of a wide variety of Pt(ii) complexes with aryl guanidines and their potential application as anticancer agents have been explored. A relatively facile synthesis of cyclometallated Pt(ii) complexes of arylguanidines, preparation of Pt(ii) guanidine coordination complexes and an in situ activation of platinum arylguanidine complexes with acetonitrile to create a bidentate aryl iminoguanidine Pt(ii) complex were achieved. Cyclometallation methodology was extended to create a water-stable conjugate incorporating two Pt(ii) ions and a diaryl bis-guanidine DNA minor groove binder. Several crystal structures were obtained confirming these complexation modes. The cyclometallated Pt(ii) complexes were particularly stable to aqueous environments and were tested for Reactive Oxygen Species generation and anticancer activity in a leukaemia cancer cell line.
More Related Videos
11:14Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Related Concept Videos
Coordination Number and Geometry
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Phase II Reactions: Miscellaneous Conjugation Reactions
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
Valence Bond Theory
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Complexometric Titration: Ligands