Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pore Transport and Ion-Pair Transport

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...

Factors Influencing Drug Absorption: Physicochemical Parameters

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Zwitterionic Sulfadiazine-Based Micelle Achieves Effective Drug Delivery to Glioblastoma by Overcoming Multiple Biological Barriers.

Journal of the American Chemical Society·2025

Same author

Correction to "Biomimetic Dual-Target Theranostic Nanovaccine Enables Magnetic Resonance Imaging and Chemo/Chemodynamic/Immune Therapy of Glioma".

ACS applied materials & interfaces·2025

Same author

Honokiol ameliorates angiotensin II-induced cardiac hypertrophy by promoting dissociation of the Nur77-LKB1 complex and activating the AMPK pathway.

Journal of cellular and molecular medicine·2023

Same author

miR-HCC2 suppresses hepatitis B virus replication by inhibiting the activity of the enhancer I/X promoter.

Archives of virology·2023

Same author

Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.

NeuroImage·2023

Same author

Genomic Epidemiology of Treponema pallidum and Circulation of Strains With Diminished tprK Antigen Variation Capability in Seattle, 2021-2022.

The Journal of infectious diseases·2023

Search research articles

Related Experiment Video

Updated: May 29, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Responsive Zwitterionic Materials for Enhanced Drug Delivery.

Ke Zheng¹, Xumei Ouyang², Hong Xie³

¹School of Materials Science and Engineering, Dongguan University of Technology, Dongguan, Guangdong 523808, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|February 5, 2025

Summary

This summary is machine-generated.

Responsive zwitterionic materials offer enhanced antitumor drug delivery by overcoming biological barriers. These advanced materials respond to internal signals, improving therapeutic efficacy and simplifying molecular design.

More Related Videos

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Related Experiment Videos

Last Updated: May 29, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery Systems

Background:

Zwitterionic materials are known for antifouling properties, extending nanocarrier circulation time.
Classical zwitterionic materials primarily address the blood circulation barrier in antitumor drug delivery.
Multiple biological barriers (e.g., tumor interstitial pressure, lysosomal barrier) limit conventional nanocarrier efficiency.

Purpose of the Study:

To review recent advancements in responsive zwitterionic materials for overcoming multiple biological barriers in antitumor drug delivery.
To highlight zwitterionic materials that respond to endogenous stimuli without additional responsive groups.
To discuss the prospects and challenges of these advanced materials in cancer therapy.

Main Methods:

Literature review of recent progress in responsive zwitterionic materials.
Analysis of zwitterionic materials responding to pH, temperature, enzymes, or reactive oxygen species.
Discussion of molecular design and stimuli-responsiveness.

Main Results:

Responsive zwitterionic materials demonstrate potential to overcome multiple biological barriers beyond mere antifouling.
These materials can be engineered to respond to specific biological signals, enhancing targeted delivery.
The intrinsic responsiveness simplifies molecular structure, maintaining ease of synthesis.

Conclusions:

Responsive zwitterionic materials represent a significant advancement over traditional antifouling agents for antitumor drug delivery.
Further research into responsive zwitterionic materials is crucial for developing more effective cancer therapies.
These materials offer a promising strategy to enhance drug delivery efficiency and reduce side effects.