Related Experiment Video
Updated: May 29, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Clinical characteristics and risk model of lower gastrointestinal involvement in systemic sclerosis
Shihan Xu1, Haochen Huang1, Jiaxin Zhou1
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College; National Clinical Research Centre for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Objectives:
Systemic sclerosis (SSc) is a systemic autoimmune disease that could involve multiple organs. Lower gastrointestinal involvement (LGIT) in systemic sclerosis (SSc-LGIT) is a serious manifestation and has a poor prognosis. This study aims to explore the related risk factors of SSc-LGIT that require hospitalisation and build a clinical risk model.
Methods:
SSc patients with LGIT admitted to Peking Union Medical College Hospital (PUMCH) were enrolled between December 2003 and December 2023. The controls were selected in SSc patients without LGIT in the same period after matching age and gender at a ratio of 1:3. Clinical data of both groups was collected to build the SSc-LGIT clinical prediction model by machine learning using R software.
Results:
A total of 42 SSc patients with LGIT and 126 matched SSc patients without LGIT were enrolled. Compared to the control group, SSc-LGIT patients had lower level of body mass index (BMI), haemoglobin (HB), albumin (ALB). Cardiomyopathy and puffy finger were more common, but arthritis/arthralgia was less. Higher hs-CRP and a higher rate of anti-Ro-52 antibody positivity were found in these patients. A multivariate analysis revealed BMI, cardiomyopathy, HB, ALB, hs-CRP as independent related factors for SSc-LGIT, and a clinical risk model containing these five items was built.
Conclusions:
A clinical risk model of SSc-LGIT was established and it has demonstrated capability in predicting the risk of severe lower gastrointestinal involvement in systemic sclerosis.
Related Concept Videos
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...