Survival analysis between different treatment strategies of mixed adenoneuroendocrine carcinoma (MANEC): a population-based study
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View abstract on PubMed
Summary
This summary is machine-generated.Surgery generally improves survival for mixed adenoneuroendocrine carcinoma (MANEC), while radiotherapy offers no benefit. Chemotherapy
Area Of Science
- Oncology
- Gastroenterology
- Surgical Oncology
Background
- Mixed adenoneuroendocrine carcinoma (MANEC) is a rare and heterogeneous malignancy.
- There is a lack of established treatment standards for MANEC.
- Understanding treatment impacts is crucial for improving patient outcomes.
Purpose Of The Study
- To investigate the prognostic significance of various treatment modalities in MANEC.
- To compare survival outcomes based on surgical intervention, radiotherapy, and chemotherapy.
- To identify factors influencing treatment efficacy in MANEC.
Main Methods
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database.
- Employed propensity score matching (PSM) for cohort balancing.
- Conducted stratified and site-specific survival analyses.
Main Results
- Surgery was associated with improved survival in most MANEC cases, except for small intestine MANEC.
- Radiotherapy showed no significant survival benefit and was linked to poorer prognosis in some analyses.
- Chemotherapy effects were inconsistent, showing benefits in advanced stages and specific sites (hepatic-biliary-pancreatic), but not early stages.
Conclusions
- Surgical intervention generally enhances survival for MANEC patients.
- Radiotherapy does not appear to confer survival advantages for MANEC.
- The efficacy of chemotherapy in MANEC is variable and depends on disease stage and treatment combinations.
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