Case report: prosthetic valve endocarditis caused by Pseudallescheria boydii and Clostridium limosum

This report describes a patient with a combined infection due to Pseudallescheria boydii and Clostridium limosum on a prosthetic dura mater aortic valve homograft. While this patient had C. limosum only growing in blood cultures, both organisms were isolated from the surgically resected aortic valve. Because P. boydii is generally resistant to amphotericin B but susceptible to miconazole, accurate differentiation of P. boydii from other fungi which may appear similarly in tissue sections (e.g., aspergillus) is important.