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Spatial Resolution Measurement of Microviscosity Using Length-Regulated Aggregation-Induced Emission Probes
Xiaofang Tang1, Mengyan Li2, Weijiang Guan2
1Pingyuan Laboratory, College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Analytical Chemistry
|February 5, 2025
Summary
New aggregation-induced emission (AIE) probes precisely measure microviscosity in self-assembled systems. These probes map viscosity gradients in micelles, hydrogels, and food, aiding application optimization.
Area of Science:
- Materials Science
- Chemical Engineering
- Biotechnology
Background:
- Measuring microviscosity gradients in self-assembled systems is vital for applications.
- Challenges include spatial barriers, polarity interference, and lack of specific probes.
Purpose of the Study:
- To develop novel aggregation-induced emission (AIE) probes for precise microviscosity measurement.
- To overcome limitations of existing methods for spatial microviscosity analysis.
Main Methods:
- Synthesized three length-regulated AIE probes with varying alkyl chain lengths.
- Tested probe sensitivity, polarity independence, and localization in micelles.
- Applied probes to monitor microviscosity in hydrogels and food thickeners.
Main Results:
- AIE probes exhibited high sensitivity (0.81) across a wide viscosity range (2-435 mPa s).
- Luminescence remained unaffected by environmental polarity, ensuring accurate readings.
- Probes localized in different micelle regions, revealing highest viscosity in the core.
Conclusions:
- Length-regulated AIE probes offer a robust solution for spatial microviscosity measurement.
- These probes are effective in diverse systems like micelles, hydrogels, and food products.
- Demonstrated potential for optimizing self-assembled systems in various applications.
