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Cognitive Processing Therapy for Posttraumatic Stress Disorder in Japan: A Randomized Clinical Trial.

Masaya Ito¹, Akiko Katayanagi^1,2, Mitsuhiro Miyamae¹

¹National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Tokyo, Japan.

JAMA Network Open

|February 5, 2025

Summary

Cognitive Processing Therapy (CPT) effectively reduces posttraumatic stress disorder (PTSD) symptoms in Japanese outpatients. This study provides crucial evidence for CPT

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Area of Science:

Psychiatry
Clinical Psychology
Trauma Studies

Background:

Cognitive Processing Therapy (CPT) is an established treatment for posttraumatic stress disorder (PTSD).
Limited evidence exists regarding CPT's efficacy in East Asian populations.
There is a need to evaluate CPT's effectiveness in non-Western clinical settings.

Purpose of the Study:

To assess the effectiveness of CPT combined with treatment as usual (CPT-TAU) compared to waiting list with treatment as usual (WL-TAU) for PTSD outpatients in Japan.
To determine if CPT can reduce PTSD symptoms in a Japanese medical context.

Main Methods:

A 16-week, single-center, assessor-blinded, parallel-group randomized clinical trial was conducted.
Adult outpatients diagnosed with PTSD were recruited from a national psychiatric referral hospital in Tokyo.
Participants were randomized to either CPT-TAU (12 weekly sessions) or WL-TAU.

Main Results:

The CPT-TAU group demonstrated a significant reduction in PTSD symptoms, as measured by the Clinician-Administered PTSD Scale (CAPS-5).
CPT-TAU showed superiority across all secondary outcomes, including depression, suicidal ideation, and disability.
The CPT-TAU group experienced a low dropout rate and no serious adverse events compared to the WL-TAU group.

Conclusions:

CPT, when provided with treatment as usual, is effective in reducing PTSD symptoms among outpatients in a Japanese setting.
These findings support the broader application of CPT in East Asian populations.
The study strengthens the evidence base for CPT as a viable treatment option for PTSD globally.