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Related Experiment Videos

Three-dimensional structure of calmodulin.

Y S Babu, J S Sack, T J Greenhough

    Nature
    |May 2, 1985
    PubMed
    Summary
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    The 3D structure of calmodulin reveals two lobes linked by an alpha-helix, binding calcium ions. This structure may explain calmodulin

    Area of Science:

    • Biochemistry
    • Structural Biology
    • Molecular Biology

    Background:

    • Calmodulin is a crucial calcium-binding protein involved in cellular signaling.
    • Understanding its three-dimensional structure is key to elucidating its function.

    Purpose of the Study:

    • To determine the high-resolution three-dimensional structure of calmodulin.
    • To provide insights into the structural basis of calcium binding and protein interactions.

    Main Methods:

    • X-ray crystallography was employed to determine the structure.
    • Data was collected and processed to achieve 3.0 A resolution.

    Main Results:

    • The determined structure shows calmodulin comprises two globular lobes.

    Related Experiment Videos

  • These lobes are connected by a long, exposed alpha-helix.
  • Each lobe contains helix-loop-helix domains that bind two calcium ions.

    • Conclusions:

    • The structure provides a detailed model of calmodulin's calcium-binding mechanism.
    • The central alpha-helix is a potential site for interactions with drugs and other proteins.
    • This structural information can guide the development of calmodulin-targeting therapeutics.