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Updated: May 29, 2025

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae
Published on: April 30, 2018
ARID1A: Multiple functions in human pregnancy
Chongying Zhu1, Bingquan Zhu2, Shouying Xu3
1National Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China; The Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.
Abstract:
AT-rich interacting domain containing respectively protein 1 A (ARID1A), a key member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, has been shown to play an important role in various physiological processes and diseases including female reproductive tumors, such as ovarian cancer and breast cancer. In addition to the studies regarding ARID1A expression and function in cancer, recent findings elucidate its important role in maintaining normal tissue homeostasis and cell differentiation by controlling chromatin remodeling and transcription factors recruitment. In the context of human pregnancy, ARID1A has been implicated in several pregnancy-related complications, including gestational diabetes, preeclampsia, and intrauterine growth restriction. This review examines the current research on the role of ARID1A in pregnancy, highlighting its potential as a biomarker and therapeutic target for these complications. Understanding the involvement of ARID1A in placental function and pregnancy-related disorders may provide valuable insights for the development of novel diagnostic and therapeutic strategies.
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