Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nondisjunction

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...

piRNA - Piwi-interacting RNAs

piRNA - Piwi-interacting RNAs

PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Gonadal and Placental Hormones

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

RGS2 facilitates trophoblast function through a loop with the Hippo pathway and ubiquitination of CTGF.

Biochemical pharmacology·2026

Same author

Revisiting Home Environment in the Digital Age: Empirical Comparison of FCI Subscales With Screen Use in Rural China.

Child: care, health and development·2026

Same author

Gastrodin produces therapeutic effects against preeclampsia by activating Wnt 3a signaling and inhibiting ferroptosis.

Experimental cell research·2025

Same author

Exploring the Role of Polyunsaturated Fatty Acids in Children's Sleep.

Biomedicines·2025

Same author

Evaluation of the Dynamiker Quantitative Anti-Aspergillus Fumigatus Specific Detection for the Diagnosis of Different Kinds of Chronic Pulmonary Aspergillosis.

Infection and drug resistance·2024

Same author

FaceMotionPreserve: a generative approach for facial de-identification and medical information preservation.

Scientific reports·2024

Same journal

Successful live birth following immunomodulatory therapy in a patient with multiple recurrent pregnancy loss and massive perivillous fibrinoid deposition.

Journal of reproductive immunology·2026

Same journal

Circulating neutrophil extracellular traps and deoxyribonuclease in gestational diabetes mellitus.

Journal of reproductive immunology·2026

Same journal

Association between endometriosis and chronic endometritis: A retrospective cross-sectional study.

Journal of reproductive immunology·2026

Same journal

Inhibition of NHE1 induces trophoblast cell senescence via ADGRG6 mediated by CXCL8.

Journal of reproductive immunology·2026

Same journal

Combined spermidine and umbilical cord mesenchymal stem cell therapy repairs endometrial injury in mice via IL-10/Treg-Dependent immune microenvironment modulation.

Journal of reproductive immunology·2026

Same journal

Vaginal versus cervical types of visible fetal membranes in cervical insufficiency: Clinical characteristics and pathophysiology.

Journal of reproductive immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 29, 2025

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

ARID1A: Multiple functions in human pregnancy.

Chongying Zhu¹, Bingquan Zhu², Shouying Xu³

¹National Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China; The Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.

Journal of Reproductive Immunology

|February 5, 2025

Summary

This summary is machine-generated.

The AT-rich interacting domain containing protein 1A (ARID1A) is crucial for normal pregnancy. Research highlights its role in complications like preeclampsia and its potential as a therapeutic target.

Keywords:

ARID1A Gestational diabetes Intrauterine growth restriction Preeclampsia Pregnancy

More Related Videos

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Related Experiment Videos

Last Updated: May 29, 2025

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Area of Science:

Molecular Biology
Genetics
Reproductive Medicine

Background:

AT-rich interacting domain containing protein 1A (ARID1A) is a key component of the SWI/SNF chromatin remodeling complex.
ARID1A is implicated in various physiological processes, cell differentiation, and diseases, including female reproductive cancers.
Recent research suggests ARID1A's involvement in maintaining normal tissue homeostasis.

Purpose of the Study:

To review the current research on the role of ARID1A in human pregnancy.
To highlight ARID1A's involvement in pregnancy-related complications.
To explore ARID1A's potential as a biomarker and therapeutic target for pregnancy disorders.

Main Methods:

Literature review of existing studies on ARID1A and pregnancy.
Analysis of ARID1A's function in chromatin remodeling and transcription factor regulation.
Examination of ARID1A's association with pregnancy complications such as gestational diabetes, preeclampsia, and intrauterine growth restriction.

Main Results:

ARID1A plays a significant role in normal tissue homeostasis and cell differentiation.
Dysregulation of ARID1A is linked to several pregnancy complications.
ARID1A's function is critical for maintaining placental health and function.

Conclusions:

ARID1A is a critical factor in human pregnancy and placental development.
ARID1A's role in pregnancy complications warrants further investigation.
ARID1A presents potential as a diagnostic biomarker and therapeutic target for pregnancy-related disorders.