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Pneumococcal revaccination in pediatric patients with sinusitis.
William G Cohen1, Chau Phung2, Dominick Rich2
1Department of Otolaryngology- Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
International Journal of Pediatric Otorhinolaryngology
|February 5, 2025
Summary
A pneumococcal polysaccharide vaccine booster dose (PPSV23) significantly reduced healthcare visits and antibiotic prescriptions for pediatric sinusitis patients. This finding includes immunocompromised children, highlighting the vaccine
Area of Science:
- Pediatric infectious diseases
- Vaccinology
- Public health
Background:
- Sinusitis is a common pediatric diagnosis.
- Low pneumococcal antibody titers may increase susceptibility to infections.
- Pneumococcal polysaccharide vaccine (PPSV23) is used to prevent pneumococcal disease.
Purpose of the Study:
- To assess the association between a PPSV23 booster dose and healthcare utilization in pediatric patients with sinusitis.
- To evaluate the impact of PPSV23 on sinusitis-related healthcare encounters and antibiotic prescriptions.
Main Methods:
- Retrospective analysis of medical records for pediatric patients (age 2-16) with sinusitis and PPSV23 booster.
- Measured sinusitis-related healthcare encounters and antibiotic prescriptions for 2 years pre- and post-vaccination.
- Used mixed effects negative binomial regression to compare pre- and post-vaccination utilization.
Main Results:
- A total of 233 pediatric patients were included.
- Healthcare encounters decreased by 51.1% and antibiotic prescriptions by 51.3% post-PPSV23 vaccination (p < 0.001).
- Significant reductions were also observed in immunocompromised children.
Conclusions:
- PPSV23 booster vaccination is associated with a significant decrease in healthcare utilization and antibiotic use for pediatric sinusitis.
- The findings support the use of PPSV23 in managing pediatric sinusitis, particularly in those with suspected low pneumococcal antibody titers.
- This intervention shows promise in reducing the burden of sinusitis-related morbidity in children.
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