Nonenzymatic glucose electrochemical sensor based on Pd-Cu bimetallic aerogels

This study introduces a novel nonenzymatic glucose electrochemical sensor based on palladium-copper bimetallic aerogels (Pd-Cu BMA) synthesized through a facile self-assembly reduction method. The Pd-Cu BMA exhibits a three-dimensional network structure formed by interconnected nanowires, which facilitates rapid electron transfer and offers abundant active sites for catalysis. Benefiting from the synergistic effect of Pd and Cu, the Pd-Cu (2:1) aerogels demonstrates remarkable electrocatalytic activity and stability under neutral conditions. Specifically, this sensor achieves a rapid response to glucose oxidation at an applied potential of 0 V, with a linear detection range up to 20 mM and a limit of detection as low as 43.4 μM. Notably, it maintains high catalytic activity over one month and shows excellent anti-interference performance against common physiological interferents. For practical application, the sensor can accurately detect additional glucose in diluted serum within the concentration range of 1-20 mM and in undiluted serum from 1 to 4 mM, thereby validating its potential for real-time monitoring of glucose levels in physiological samples. This innovative design of Pd-Cu bimetallic aerogels not only enhances the performance of nonenzymatic glucose sensors but also paves the way for the development of advanced materials for point-of-care diagnostics.