Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Valves01:16

Heart Valves

4.2K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
4.2K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

513
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
513
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

147
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
147
Development of the Heart01:27

Development of the Heart

848
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
848

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What is the role of apical ventriculotomy in children and young adults with hypertrophic cardiomyopathy?

Congenital heart disease·2018
Same author

The Brockenbrough-Braunwald-Morrow sign.

The Journal of thoracic and cardiovascular surgery·2018
Same author

Response by Nguyen et al to Letter Regarding Article, "Early Outcomes of Repair of Left Ventricular Apical Aneurysms in Patients with Hypertrophic Cardiomyopathy".

Circulation·2018
Same author

Does septal myectomy reduce risk of sudden cardiac death in patients with hypertrophic cardiomyopathy?

The Journal of thoracic and cardiovascular surgery·2018
Same author

Hybrid alternate approach for complex radiation-induced valvular disease.

The Journal of thoracic and cardiovascular surgery·2018
Same author

Determinants of Reverse Remodeling of the Left Atrium After Transaortic Myectomy.

The Annals of thoracic surgery·2018

Related Experiment Video

Updated: May 29, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.4K

Valvular Heart Disease-A New Evolving Paradigm.

Rick A Nishimura1, Steve R Ommen1, Joseph A Dearani1

  • 1Department of Cardiovascular Medicine and the Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings
|February 5, 2025
PubMed
Summary
This summary is machine-generated.

Valvular heart disease impacts many, but early detection and intervention can improve quality of life and longevity. Recognizing subtle signs of valve disease is crucial for timely treatment and better patient outcomes.

More Related Videos

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

2.9K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

15.9K

Related Experiment Videos

Last Updated: May 29, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.4K
A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

2.9K
Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

15.9K

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Valvular Heart Disease

Background:

  • Valvular heart disease is a prevalent cardiovascular condition associated with significant morbidity and mortality.
  • Despite advances, nearly half of patients who could benefit from interventions are underdiagnosed or not referred.
  • Early identification is key to restoring quality of life and increasing longevity.

Purpose of the Study:

  • To review current diagnostic and therapeutic advancements in valvular heart disease.
  • To emphasize the importance of early recognition and intervention, even before symptom onset.
  • To highlight the role of shared decision-making in patient management.

Main Methods:

  • Review of noninvasive diagnostic tools, including echocardiography.
  • Discussion of surgical and catheter-based therapeutic options.
  • Analysis of national guidelines for intervention timing.

Main Results:

  • Echocardiography confirms valve disease presence and severity.
  • Surgical and catheter-based therapies offer improved outcomes.
  • Emerging evidence suggests early intervention can prevent ventricular dysfunction.

Conclusions:

  • Early diagnosis and intervention in valvular heart disease are critical for improved patient outcomes.
  • Shared decision-making, considering patient needs and expectations, is essential for treatment planning.
  • Prompt recognition of valve disease, even in asymptomatic patients, is increasingly important.