Breast cancer statistics for Japan in 2022: annual report of the national clinical database-breast cancer registry-clinical implications including chemosensitivity of breast cancer with low estrogen receptor expression
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View abstract on PubMed
Summary
This summary is machine-generated.The Japanese Breast Cancer Society
Area Of Science
- Oncology
- Clinical Data Analysis
- Epidemiology
Background
- The Japanese Breast Cancer Society annually reports on breast cancer statistics in Japan.
- Data is extracted from the National Clinical Database-Breast Cancer Registry (NCD-BCR).
- The 2022 report details 102,453 cases from 1339 institutions.
Purpose Of The Study
- To present updated clinical data and statistics on breast cancer in Japan for 2022.
- To analyze patient demographics, disease stages, receptor status, and treatment modalities.
- To report on treatment outcomes, including pathological complete response rates to neoadjuvant therapy.
Main Methods
- Analysis of breast cancer cases registered in the NCD-BCR in 2022.
- Inclusion of 102,453 cases from 1339 institutions.
- Statistical analysis of patient demographics, tumor characteristics, surgical procedures, radiation therapy, and neoadjuvant chemotherapy outcomes.
Main Results
- Median age at diagnosis was 62 years; 29.4% of patients were premenopausal.
- 15.2% and 42.2% diagnosed with stage 0 and I disease, respectively.
- Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) positivity rates were 78.7%, 69.4%, and 12.8%.
- 41.7% underwent breast-conserving surgery; 5.9% had breast reconstruction.
- 68.9% treated with sentinel lymph node biopsy; 7.4% with sentinel lymph node biopsy plus axillary node dissection.
- Pathological complete response (pCR) to neoadjuvant chemotherapy was 30.9%, highest (60.5%) in hormone receptor-negative/HER2-positive subtype.
Conclusions
- The 2022 report provides a comprehensive overview of breast cancer clinical data in Japan.
- Treatment patterns include high rates of breast-conserving surgery and sentinel lymph node biopsy.
- Neoadjuvant chemotherapy shows promising pCR rates, particularly in specific molecular subtypes.
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