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Updated: Jun 14, 2025
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional
Hai Le1, Daphna Fenchel2, Konstantina Dimitrakopoulou3
1Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. L.haibg@gmail.com.
Abstract:
Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population. This study examined the association between ASD polygenic risk score (PRS) and volumes of the frontal, temporal, parietal, occipital, fronto-temporal and parieto-occipital lobes in 273 term-born infants of European ancestry in the developing Human Connectome Project. ASD PRS was positively associated with frontal (β = 0.027, pFDR = 0.04) and fronto-temporal (β = 0.024, pFDR = 0.01) volumes, but negatively with parietal (β = -0.037, pFDR = 0.04) and parieto-occipital (β = -0.033, pFDR = 0.01) volumes. This preliminary result suggests the potential involvement of ASD common genetic variants in early structural variations linked to ASD.
