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Updated: Jun 26, 2026
06:56
Wet-spinning-based Molding Process of Gelatin for Tissue Regeneration
Published on: March 7, 2019
8.7K
Engineered Living Systems Based on Gelatin: Design, Manufacturing, and Applications
Zhenwu Wang1, Zeng Lin1, Xuan Mei1
1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Advanced Materials (Deerfield Beach, Fla.)
|February 6, 2025
Summary
Gelatin and its derivatives are key biomaterials for engineered living systems (ELSs), enabling advanced fabrication techniques for diverse biomedical applications like regenerative engineering and cell therapies.
Area of Science:
- Biomedical Engineering
- Materials Science
- Tissue Engineering
Background:
- Engineered living systems (ELSs) are purpose-driven assemblies of biological components for biomedical applications.
- Gelatin and its derivatives are widely used in ELSs due to their biological compatibility and tunable properties.
Purpose of the Study:
- To review the synergistic potential of gelatin derivatives and fabrication techniques in creating ELSs.
- To explore the applications of gelatin-based ELSs in various biomedical fields.
Main Methods:
- Comprehensive literature review of gelatin properties, fabrication methods, and ELS applications.
- Analysis of generic fabrication, microfluidics, and 3D printing techniques with gelatin.
- Examination of gelatin-based ELSs in regenerative engineering, cell therapies, bioadhesives, biorobots, and biosensors.
Main Results:
- Gelatin's structure, production, sources, processing, and properties are detailed.
- Various fabrication techniques utilizing gelatin and its derivatives are discussed.
- Diverse applications of gelatin-based ELSs are presented, highlighting their versatility.
Conclusions:
- Gelatin-based ELSs hold significant promise for advancing biomedical engineering.
- Future research should focus on overcoming fabrication challenges and exploring innovations in gelatin-based ELSs.
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