Physiological and pathological roles of PGAM5: An update and future trend

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Imaging Mitochondrial Ca2+ Uptake in Astrocytes and Neurons using Genetically Encoded Ca2+ Indicators GECIs
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Imaging Mitochondrial Ca2+ Uptake in Astrocytes and Neurons using Genetically Encoded Ca2+ Indicators GECIs

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Weibin He1,2, Wenlong He1,2, Zhongchan Sun1,2

  • 1Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou 510080, China.

Iscience
|February 6, 2025
PubMed

Insights

Phosphoglucomutase 5 (PGAM5) is vital for mitochondrial quality control and various cell death types. This review explores PGAM5

Area of Science:

  • Mitochondrial Biology
  • Cell Death Pathways
  • Molecular Mechanisms

Background:

  • PGAM5 is a mitochondrial phosphatase regulating mitochondrial dynamics, biogenesis, and mitophagy.
  • PGAM5 is implicated in multiple regulated cell death (RCD) pathways, including apoptosis, necroptosis, and pyroptosis.

Purpose of the Study:

  • To deepen the understanding of PGAM5's role in mitochondrial quality control (MQC) and RCDs.
  • To summarize recent findings on PGAM5's novel functions in cellular senescence, lipid metabolism, and immune responses.
  • To discuss PGAM5's involvement in pathological conditions and suggest future research directions.

Main Methods:

  • Literature review of existing studies on PGAM5.
  • Synthesis of current knowledge on PGAM5's functions and disease associations.
  • Analysis of recent research on novel PGAM5 roles.

Main Results:

  • PGAM5 is a key regulator of MQC processes.
  • PGAM5 participates in diverse RCD pathways.
  • Emerging roles of PGAM5 in senescence, metabolism, and immunity are highlighted.

Conclusions:

  • PGAM5 plays a multifaceted role in cellular homeostasis and death.
  • PGAM5 is implicated in the pathogenesis of cardiovascular, hepatic, neurological, and neoplastic diseases.
  • Further research into PGAM5 offers therapeutic potential for various diseases.
Keywords:
Biological sciencesMolecular physiologyPathology

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