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Isotretinoin - Induced AGEP: A Case Report
Hend M Alotaibi1, Sultan AlNasser1, Abdulelah Aldossari2
1Department of Dermatology, College of Medicine, King Saud University and King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia.
International Medical Case Reports Journal
|February 6, 2025
Summary
Isotretinoin can trigger Acute Generalized Exanthematous Pustulosis (AGEP), a severe skin reaction. Early identification through clinical assessment is vital for managing this rare dermatological adverse event.
Area of Science:
- Dermatology
- Pharmacovigilance
Background:
- Acute Generalized Exanthematous Pustulosis (AGEP) is a severe dermatological reaction with rapid onset of erythema and sterile pustules.
- Common triggers include antibiotics, antifungals, antimalarials, and diltiazem.
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Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...