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Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals

Yuanqing Wang1,2, Xiaojie Jiang3, Yuan Xi3

  • 1Institute of Critical Care Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.

Frontiers in Microbiology
|February 6, 2025
PubMed

Insights

Three new cycloviruses were discovered in human blood using viral metagenomics. These viruses, sharing similarities with those in Africa, may play a role in host transmission and chronic infections.

Area of Science:

  • Virology
  • Genomics
  • Infectious Diseases

Background:

  • The Circoviridae family includes Circovirus and Cyclovirus genera.
  • Cycloviruses have been detected in human serum, but research remains limited.
  • Their presence in chronic HBV, HCV, or HIV-infected individuals and asymptomatic donors is noted.

Purpose of the Study:

  • To identify and characterize novel cycloviruses in the human blood virome.
  • To analyze the genetic makeup and evolutionary relationships of newly discovered cycloviruses.
  • To understand the potential implications of cycloviruses in human health and disease.

Main Methods:

  • Viral metagenomics was employed to mine and analyze the human blood virome.
  • Bioinformatic tools were used for genome identification, analysis, and visualization.
  • Phylogenetic and distance matrix analyses were performed to assess sequence similarity.

Main Results:

  • Three novel cyclovirus genomes were identified, each encoding Rep and Capsid proteins.
  • These cycloviruses exhibit high sequence similarity to viruses found in human and animal populations in Africa.
  • The findings confirm the existence of previously uncharacterized cycloviruses in human blood.

Conclusions:

  • The study confirms the presence of novel cycloviruses in human blood, with potential links to African viral strains.
  • These findings highlight the need for further research into cyclovirus pathogenesis, host immunity, and cross-species transmission.
  • Understanding cycloviruses is crucial for assessing their broader impact on human and animal health.

Keywords:
Circoviridaebloodcyclovirusesphylogeneticviral metagenomics

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