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Updated: May 29, 2025

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty
Kanthi Bangalore Krishna1, Luigi Garibaldi1
1Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, UPMC Childrens Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States.
Abstract:
Pubertal onset is characterized by reactivation of the hypothalamic-pituitary-gonadal axis resulting in pulsatile gonadotropin secretion and subsequent sex steroid production. Accurate measurements of the gonadotropins and sex steroids are essential to ensure timely diagnosis of precocious puberty, so as to determine optimal management. This review summarizes the available laboratory testing for the diagnosis of puberty, discussing the different assays used while reviewing the limitations of such testing.
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