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Right heart reverse remodeling: "facta non verba "
Tommaso Recchioni1, Giovanna Manzi1, Alexandra Mihai1
1Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy.
International Journal of Cardiology. Congenital Heart Disease
|February 6, 2025
Summary
Pulmonary arterial hypertension (PAH) treatment aims to reduce pulmonary vascular resistance (PVR) for right heart reverse remodeling (RHRR). Initial triple therapy, including prostanoids, is key to achieving low mortality risk and improving PAH prognosis.
Area of Science:
- Cardiology
- Pulmonary Hypertension Research
- Right Ventricular Function
Background:
- Pulmonary arterial hypertension (PAH) involves pulmonary vascular remodeling, increasing right ventricular (RV) afterload and worsening survival.
- RV remodeling and function are critical; failure occurs when RV adaptive capacity is exceeded, leading to ventricular-arterial uncoupling and death.

