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Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

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Published on: February 1, 2012

[Lysozyme in children with acute and chronic inflammatory intestinal diseases]

W Dick, O H Braun, W Nagel

    Padiatrie Und Padologie
    |January 1, 1985
    PubMed

    Insights

    Fecal lysozyme levels are elevated in children with Rotavirus enteritis and active Crohn's disease or ulcerative colitis. Measuring fecal lysozyme can monitor disease activity and treatment effectiveness in pediatric inflammatory bowel diseases.

    Area of Science:

    • Gastroenterology
    • Biochemistry
    • Pediatrics

    Context:

    • Inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis significantly impact children's health.
    • Accurate diagnostic and monitoring tools are crucial for managing pediatric IBD and infectious enteritis.

    Purpose:

    • To investigate fecal lysozyme excretion as a potential biomarker in pediatric gastroenterological conditions.
    • To assess the correlation between fecal lysozyme levels and disease activity in Rotavirus enteritis and IBD.

    Summary:

    • Fecal lysozyme levels were significantly higher in infants with Rotavirus enteritis compared to healthy controls.
    • Elevated fecal lysozyme was observed in untreated Crohn's disease and ulcerative colitis patients.
    • Treatment with Salazosulfapyridine, Prednisone, and elemental diet led to a significant decrease in fecal lysozyme levels in IBD patients.

    Impact:

    • Fecal lysozyme excretion serves as a valuable indicator of clinical disease activity in pediatric gastroenteritis and IBD.
    • It can be utilized to monitor therapeutic efficacy and detect relapses in affected children.
    • This biomarker aids in objective assessment and management of pediatric gastrointestinal disorders.

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